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2024
Water-Mediated Synthesis of (E)-3-(1-Methyl-1H-benzo[d]imidazol-5-yl)-N-phenethylacrylamide, a Caffeic Acid Phenethyl Amide Analogue
Muppidi Subbarao, Kerwin, S. M.
Molbank, 2024, 2024, M1915
DOI: 10.3390/M1915
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Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA
Das, M. K.; Williams, E. P.; Myhre, M. W.; David, W. M.; Kerwin, S. M.
Molecules, 2024, 29, 4457
DOI: 10.3390/molecules29184457
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Flow and On-Water Synthesis and Cancer Cell Cytotoxicity of CAPA Analogues
Saucedo, A.; Subbarao, M.; Jemal, M.; Mesa-Diaz, N. L.; Smith, J. L.; Vernaza, A.; Du, L.; Kerwin, S. M.
International Journal of Molecular Sciences, 2024, 25, 8051
DOI: 10.3390/ijms25158051
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2022
Phenyliodine(III) Diacetate-Mediated Dearomatization of 2-(2-Hydroxyaryl)benzoxazoles and 2-(2-Hydroxyaryl)benzothiazoles: Regio- and Stereoselective Synthesis of Tetramethoxycyclohexenones and Bicyclo[2.2.2]octenones
Yadav, G.; Kumar, S.; Kumar, D.; Kataria, R.; Laroche, C.; Kerwin, S. M.
Journal of Molecular Structure, 2022, 1266, 133520
DOI: 10.1016/j.molstruc.2022.133520
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Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues
Theisen, P. D.; Schwartz, Z. T.; Bjornstal, O. T.; Rodebaugh, M.; Jemal, M. A.; Lee, D.; Shelton, S. D.; Zhao, Z. Z.; Du, L. Q.; Kerwin, S. M.
Molecules, 2022, 27(6), 1792
DOI: 10.3390/molecules27061792
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Spirocyclic Products via Carbene Intermediates from Thermolysis of 1,2-Dialkynylpyrrole and 1,2-Diethynylimidazole
Jewett, A. L.; Bondoc, A. J.; Gilbreath, B. L.; Reinus, B. J.; Kerwin, S. M.
Synlett, 2022, 33(07), 674-678
DOI: 10.1055/s-0041-1737937
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2019
N-Alkynyl Pyrrole Based Total Synthesis of Shensongine A
Reinus, B.; Kerwin, S. M.
Synthesis, 2019, 51(21), 4085-4105
DOI: 10.1055/s-0037-1611904
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N-Methylmesoporphyrin IX Exhibits G-Quadruplex Specific Photocleavage Activity
McBrayer, D.; Schoonover, M.; Long, K.; Escobedo, R.; Kerwin, S. M.
ChemBioChem, 2019, 20(15), 1924-1927
DOI: 10.1002/cbic.201900002
Flexible and Modular 3D-Printed Peptide Models
Kerwin, S. M.
Biochemistry and Molecular Biology Education, 2019, 47(4), 432-437
DOI: https://rdcu.be/bEbir
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2018
Preparation and Utility of N-Alkynyl Azoles in Synthesis
Reinus, B.; Kerwin, S. M.
Molecules, 2018, 24(3), 422
DOI: 10.3390/molecules24030422
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2017
A General Cu-Catalyzed N-Alkynylation Route to 2-Substituted YnPyrroles and Their Cyclization to Pyrrolo[2,1-c]oxazin-1-ones: A Formal Total Synthesis of Peramine
Reinus, B.; Kerwin, S. M.
Synthesis, 2017, 49(11), 2544-2554
DOI: 10.1055/s-0036-1588736
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Alternative DNA Structure Formation in the Mutagenic Human c-MYC Promoter
del Mundo, I.; Zewail-Foote, M.; Kerwin, S.; Vasquez, K.
Nucleic Acids Research, 2017, 45(8), 4929-4943
DOI: 10.1093/nar/gkx100
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2015
Synthesis and Evaluation of a Rationally Designed Click-Based Library for G-Quadruplex Selective DNA Photocleavage
McBrayer, D.; Kerwin, S. M.
Molecules, 2015, 20(9), 16446-16465
DOI: 10.3390/molecules200916446
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2014
Exploring the Synthetic Utility of 1-Alkynylimidazoles: Regiocontrolled Cyclization to Diverse Imidazoazines and Imidazoazoles
Laroche, C.; Gilbreath, B.; Kerwin, S. M.
Tetrahedron, 2014,
DOI: 10.1016/j.tet.2014.04.099
Development and Validation of an LC-MS Method to Determine the Pharmacokinetic Profiles of Caffeic Acid Phenethyl Amide and Caffeic Acid Phenethyl Ester in Sprague-Dawley Rats
Yang, J.; Bowman, P. D.; Kerwin, S. M.; Stavchansky, S.
Biomedical Chromatography, 2014, 28, 241-246
DOI: 10.1002/bmc.3011
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A Concise Synthesis of Rooperol and Related 1,5-Diarylpent-1-en-4-ynes
Kerwin, S. M.; Cha, J.
Tetrahedron Letters, 2014, 55, 137–141
DOI: 10.1016/j.tetlet.2013.10.138
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2013
A Fluorescence-Based Assay for p38α Docking Site Binders: Identification of the Hypoxis Natural Product Rooperol as a Novel p38α Kinase Inhibitor
Li, J.; Kaoud, T. S.; LeVieux, J.; Gilbreath, B.; Moharana, S.; Dalby, K. N.; Kerwin, S. M.
ChemBioChem, 2013, 14, 66-71
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cbic.201200529
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2012
G-Quadruplex DNA Cleavage Preference and Identification of a Perylene Diimide G-Quadruplex Photocleavage Agent Using a Rapid Fluorescent Assay
Schoonover, M.;Kerwin, S. M.
Bioorganic & Medicinal Chemistry, 2012, 20, 6904–6918
DOI: 10.1016/j.bmc.2012.10.017
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2011
Cytotoxic 1,2-Dialkynylimidazole-Based Aza-Enediynes: Aza-Bergman Rearrangement Rates Do Not Predict Cytotoxicity
Laroche, C.; Li, J.; Kerwin, S. M.
Journal of Medicinal Chemistry, 2011, 54, 5059-5069
DOI: 10.1021/jm200289j
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2010
Structure-Activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities
Wang, X.; Stavchansky, S.; Kerwin, S. M.; Bowman, P. D.
European Journal of Pharmacology, 2010, 635, 16-22
DOI: 10.1016/j.ejphar.2010.02.034
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Cyclization Kinetics and Biological Evaluation of an Anticancer 1,2-Dialkynylimidazole
Laroche, C.; Li, J.; Golzales, C.; David, W. M.; Kerwin, S. M.
Organic & Biomolecular Chemistry, 2010, 8, 1535–1539
DOI: 10.1039/B925261D
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Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPE) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE)
Yang, J.; Marriner, G. A.; Wang, X.; Bowman, P. D.; Kerwin, S. M.
Bioorganic & Medicinal Chemistry, 2010, 18, 5032-5038
DOI: 10.1016/j.bmc.2010.05.080
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2009
An Improved Synthesis of N’-Nitroso-Nornicotine-5’-Acetate
Marriner, W. A.; Kerwin, S. M.
Journal of Organic Chemistry, 2009, 74, 2891-2892
DOI: 10.1021/jo9000417
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