Water-Mediated Synthesis of (E)-3-(1-Methyl-1H-benzo[d]imidazol-5-yl)-N-phenethylacrylamide, a Caffeic Acid Phenethyl Amide Analogue. Molbank 2024, 2024, M1915.. https://doi.org/10.3390/M1915
Muppidi Subbarao and Sean M. Kerwin *
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Das, M. K.; Williams, E. P.; Myhre, M. W.; David, W. M.; Kerwin, S. M. Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA. Molecules 2024 29, 4457.
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Saucedo, A.; Subbarao, M.; Jemal, M.; Mesa-Diaz, N. L.; Smith, J. L.; Vernaza, A.; Du, L., Kerwin, S. M. Flow and on-water synthesis and cancer cell cytotoxicity of CAPA analogues. Int. J. Mol. Sci. 2024, 25, 8051.​
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Yadav, G.; Kumar, S.; Kumar, D.; Kataria, R., Laroche, C.; Kerwin, S. M. Phenyliodine(III) diacetate-mediated dearomatization of 2-(2-hydroxyaryl)benzoxazoles and 2-(2-hydroxyaryl)benzothiazoles: Regio- and stereoselective synthesis of tetramethoxycyclohexenones and bicyclo[2.2.2]octenones, J. Mol. Structure 2022, 1266, 133520. ​
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Schwartz, Z. T.; Bjornstal, O. T.; Rodebaugh, M.; Jemal, M. A.; Lee, D.; Shelton, S. D.; Zhao, Z. Z.; Du, L. Q.; Kerwin, S. M.; Theisen, P. D., Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues. Molecules 2022, 27 (6) 1792.
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Jewett, A. L.; Bondoc, J. A.; Gilbreath, B. L.; Reinus, B. J.; Kerwin, S. M., Spirocyclic Products via Carbene Intermediates from Thermolysis of 1,2-Dialkynylpyrrole and 1,2-Diethynylimidazole. Synlett 2022, 33 (07), 674-678.
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Reinus, B.; Kerwin, S. M. "N-Alkynyl Pyrrole Based Total Synthesis of Shensongine A" Synthesis, 2019, DOI: 10.1055/s-0037-1611904.
McBrayer, D.; Schoonover, M.; Long, K.; Escobedo, R.; Kerwin, S. M. "N-Methylmesoporphyrin IX Exhibits G-Quadruplex Specific Photocleavage Activity" Chembiochem. 2019 Aug 1;20(15):1924-1927. https://doi.org/10.1002/cbic.201900002
Kerwin, S. M. "Flexible and Modular 3-D Printed Peptide Models" Biochem Mol Biol Educ. 2019 Jul;47(4):432-437. https://rdcu.be/bEbir
Reinus, B.; Kerwin, S. M. "Preparation and Utility of N-Alkynyl Azoles in Synthesis" Molecules, 2018, 24(3), 422. https://doi.org/10.3390/molecules24030422
Reinus, B.; Kerwin, S. M. “A General Cu-Catalyzed N-Alkynylation Route to 2-Substituted Ynpyrroles and Their Cyclization to pyrrolo[2,1-c]oxazin-1-ones: A Formal Total Synthesis of Peramine“ Synthesis, 2017, 49(11), 2544–2554. doi: 10.1055/s-0036-1588736, .
del Mundo, I.; Zewail-Foote, M.; Kerwin, S.; Vasquez, K. “Alternative DNA structure formation in the mutagenic human c-MYC promoter” Nucleic Acids Res. 2017 May 5;45(8):4929-4943. doi: 10.1093/nar/gkx100.
McBrayer, D.; Kerwin, S. M.; "Synthesis and Evaluation of a Rationally Designed Click-based Library for G-Quadruplex Selective DNA Photocleavage” Molecules. 2015 Sep 10;20(9):16446-65. doi: 10.3390/molecules200916446.
Laroche C.; Gilbreath B.; Kerwin S.M.; "Exploring the synthetic utility of 1- alkynylimidazoles: Regiocontrolled cyclization to diverse imidazoazines and imidazoazoles" Tetrahedron 2014, doi: 10.1016/j.tet.2014.04.099.
Yang, J.; Bowman, P. D.; Kerwin, S. M.; Stavchansky, S. “Development and validation of an LCMS method to determine the pharmacokinetic profiles of caffeic acid phenethyl amide and caffeic acid phenethyl ester in Sprague-Dawley rats” Biomed. Chromatogr. 2014, 28, 241-246, doi:10.1002/bmc.3011.
Kerwin, S. M.; Cha, J.; "A concise synthesis of rooperol and related 1,5-diarylpent-1-en-4-ynes" Tet. Lett. 2013, 55, 137-141, doi: 10.1016/j.tetlet.2013.10.138.
Li, J.; Kaoud, T. S.; LeVieux, J.; Gilbreath, B.; Moharana, S.; Dalby, K, N.;Kerwin, S. M. “A fluorescence-based assay for p38a docking site binders: Identification of the Hypoxis natural product rooperol as a novel p38a kinase inhibitor” ChemBioChem, 2013, 14, 66-71, doi: 10.1002/cbic.201200529.
Schoonover, M.; Kerwin, S. M. “G-Quadruplex DNA Cleavage Preference and Identification of a Perylene Diimide G-Quadruplex Photocleavage Agent Using a Rapid Fluorescent Assay” Bioorg. Med. Chem. 2012, 20, 6904–6918, doi: 10.1016/j.bmc.2012.10.017.
Laroche, C.; Li, J.; Kerwin, S. M. “Cytotoxic 1,2-Dialkynylimidazole-Based Aza-Enediynes: Aza-Bergman Rearrangement Rates do not Predict Cytotoxicity” J. Med. Chem. 2011, 54, 5059-5069, doi: 10.1021/jm200289j.
Wang, X.; Stavchansky, S.; Kerwin, S. M.; Bowman, P. D. “Structure-activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities. Eur. J. Pharmacol. 2010, 635, 16-22, doi: 10.1016/j.ejphar.2010.02.034.
Laroche, C.; Li, J.; Golzales, C.; David, W. M.; Kerwin, S. M. “Cyclization Kinetics and Biological Evaluation of an Anticancer 1,2-Dialkynylimidazole”Org. Biomol. Chem. 2010, 8, 1535 – 1539, doi: 10.1039/B925261D.
Yang, J.; Marriner, G. A.; Wang, X.; Bowman, P. D.; Kerwin, S. M.; Stavchansky, S. “Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPE) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE)” Bioorg. Med. Chem. 2010, 18, 5032-5038, doi: 10.1016/j.bmc.2010.05.080.
Marriner, W. A.; Kerwin, S. M. “An Improved Synthesis of N’-Nitroso-Nornicotine-5’-Acetate” J. Org. Chem. 2009, 74, 2891-2892, doi: 10.1021/jo9000417.
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